hrp0097p2-305 | Late Breaking | ESPE2023

Precocious puberty and fluctuating β-HCG levels in a boy leading to diagnoses of klinefelter syndrome and mediastinal germ cell tumor

Shilo Smadar , Amar Shirah , Shefer Averbuch Noa , Rosenbaum Efraim , Phillip Moshe , Lazar Liora

Background: GnRH-independent precocious puberty with elevated β-human chorionic gonadotropin (β-HCG) levels can be the presenting sign of secreting germ cell tumor (GCT) in boys. These tumors are very rare, but have a higher incidence rate in Klinefelter syndrome.Case presentation: Here we report a case of a 7.3 year-old boy presenting with precocious puberty. In his physical examination, his height was 143.0 c...